Why the ongoing mass vaccination experiment drives a rapid evolutionary response of SARS-CoV-2

Arwen~The article is quite lengthy and can be a challenging read with all the medical and biological technical terms, but persevere, you will get the gist of it.

Excerpt from article~

” It is fair to expect that the widespread presence of full-fledged, S-specific vaccinal Abs will eventually cause vaccine-resistant variants to dominate and further expand in the viral population. This is to say that ongoing mass vaccination campaigns will inevitably entail full resistance of Sars-CoV-2 to all S-targeting Covid-19 vaccines and are, therefore, highly likely to lead to an impressive wave of infection and disease in vaccinees, especially in those who have not previously experienced Covid-19 disease.

It suffices to acknowledge that the ongoing convergent evolution of new variants is driven by natural selection pressure to conclude that mass vaccination campaigns conducted in the heat of a pandemic are now promoting expansion of immune escape variants that vaccines will eventually no longer be capable of protecting against.



The chicken-and-egg problem (which came first?)

Excerpt from article~

“Let’s now comment on a few of these blunt statements:

Unvaccinated people do more than merely risk their own health. They’re also a risk to everyone if they become infected with coronavirus, infectious disease specialists say

Comment: Not true. Unvaccinated people have the more reliable protection as they can deal with all Sars-CoV-2 variants. Their protection is merely threatened by the enhanced circulation of more infectious variants, the adaptation and spread of which is promoted by those who exert strong (but suboptimal!) immune selection pressure, i.e., vaccinees. To the extent that non-vaccinated people further adhere to infection prevention measures and -not at least – avoid close contact with vaccinees, the likelihood for them to become seriously ill remains reasonably low (but clearly higher as during the first 10 months of the pandemic where no variants were circulating). This particularly applies to children and youngsters in good health. As viral transmission by asymptomatically infected, non-vaccinated individuals is low and short-lived, they do not constitute a ‘factory’ of variants that poses a substantial risk to others.

That’s because the only source of new coronavirus variants is the body of an infected person.”

Comment: Vaccinees get infected all the time. They cannot contain the variants as shown in a multitude of publications and breakthrough reports. They are not only a source of asymptomatic transmission but even a breeding ground for steadily evolving immune escape variants.

“Unvaccinated people are potential variant factories,” Dr. William Schaffner, a professor in the Division of Infectious Diseases at Vanderbilt University Medical Center, told CNN Friday.

Comment: This doesn’t make any scientific sense. See above. They should show us the data and perform a comparative analysis on vaccinees compared to non-vaccinated individuals. They should show us which group is evolving more problematic variants, the vaccinees or the non-vaccinated.

The more unvaccinated people there are, the more opportunities for the virus to multiply,” Schaffner said. “When it does, it mutates, and it could throw off a variant mutation that is even more serious down the road.”

Comment: This is the ludicrous mantra of the WHO (see my previously mentioned article). What makes immune escape variants problematic is when they get selected and can subsequently adapt to the population. S-directed immune escape variants are preferably selected in vaccinees and the higher the vaccination coverage rate, the more rapidly and easily they will adapt to the population and become dominant.

Conclusion: The statements of these professors are not based on sound scientific grounds and ignore the basic principles of natural selection forces that are driving viral evolutionary dynamics. Instead, they’re based on simplistic mantras that can easily be conveyed to the broader public but do not match at all the molecular analysis of naturally selected mutations that are currently seen by genomic epidemiologists to be evolving under rising population-level immunity towards antibodies directed at S protein. The latter happens to be the target of the vaccines….So, don’t they think mass vaccination may help a bit to raise this selective immune pressure?

Again, we call for solidarity and not discrimination. All people deserve a treatment that can ultimately protect them from severe disease and long Covid. We do not want to end up with a society where some professors or, for that matter, any government agency, are holding people responsible for decisions they have to make based on their best understanding of never-ending contradictory messages. At this stage, science and common sense dictate that people should be treated at an early stage of clinical signs and symptoms. An ‘infection and treatment’ approach is not only very safe but it likely enables naturally protective immune mechanisms in both vaccinated and non-vaccinated people (even if they did not contract the disease in the past!). It may not prevent subsequent infection and mild disease but it should clearly protect against severe disease by virtue of priming of CoV-specific cytotoxic T cells (just as much as immunity acquired upon recovery from natural disease does). If treatment is only initiated when early signs and symptoms manifest, children and youngsters in good health will still be given the opportunity to eliminate the virus naturally at an early stage of infection by virtue of their innate antibodies.”

Read article in full here~https://www.geertvandenbossche.org/post/the-chicken-and-egg-problem-which-came-first?fbclid=IwAR0EgcaNYmja0tWVgTYxD3GlGZNYPd0wlW1NeG7OAvbW9QMG_gYbaKmZB20

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