Why the ongoing mass vaccination experiment drives a rapid evolutionary response of SARS-CoV-2

Arwen~The article is quite lengthy and can be a challenging read with all the medical and biological technical terms, but persevere, you will get the gist of it.

Excerpt from article~

” It is fair to expect that the widespread presence of full-fledged, S-specific vaccinal Abs will eventually cause vaccine-resistant variants to dominate and further expand in the viral population. This is to say that ongoing mass vaccination campaigns will inevitably entail full resistance of Sars-CoV-2 to all S-targeting Covid-19 vaccines and are, therefore, highly likely to lead to an impressive wave of infection and disease in vaccinees, especially in those who have not previously experienced Covid-19 disease.

It suffices to acknowledge that the ongoing convergent evolution of new variants is driven by natural selection pressure to conclude that mass vaccination campaigns conducted in the heat of a pandemic are now promoting expansion of immune escape variants that vaccines will eventually no longer be capable of protecting against.



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